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Interactions

A. Top Drug-Drug Interactions:

1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).

2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.

3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.

Other Drug-Drug interactions:

  • Ketoconazole, itraconazole (used to manage fungal infection)
  • Protease inhibitors (used to manage HIV infection) Ex. ritonavir, lopinavir
  • Phenobarbital, phenytoin, carbamazepine (medicines used for fits)
  • Rifampicin, erythromycin, clarithromycin (medicines used for bacterial infections)
  • Other medicines used to improve blood flow to the penis (Ex. sildenafil)

B. Drug-Food Interactions:

Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:

  1. Grapefruit and Grapefruit Juice: Grapefruit can increase the levels of tadalafil in your blood by interfering with its metabolism. This may amplify side effects, such as headaches, dizziness, or low blood pressure. Avoid consuming grapefruit or grapefruit juice while taking Cialis.
  2. Alcohol: Drinking alcohol with Cialis can enhance the blood pressure-lowering effects of the medication, leading to symptoms like dizziness, lightheadedness, or fainting. Limiting alcohol intake is recommended while using Cialis.
  3. High-Fat Meals: While Cialis can be taken with or without food, consuming it with a high-fat meal may delay its onset of action. Opt for lighter meals if rapid effectiveness is needed.
  4. Caffeine: Though not a direct interaction, combining Cialis with high caffeine intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
Definition

C.

Cialis (tadalafil) can interact with certain foods and beverages, possibly altering its effectiveness or increasing the spread over the diet. Here are the key drug-food interactions your doctor has suggested:

  1. : Though not a direct interaction, combining Cialis with high alcohol intake might worsen side effects like headaches or increase heart rate in sensitive individuals.
  2. : While while drinking large amounts of high-fat meal, which can delay its onset of action,autions should be taken while using Cialis.
  3. Dehydration: Though not a direct interaction, combining Cialis with highDehydration might be recommended while using Cialis.
  4. Other Ed Drug-Interactions:Cialis can enhance the blood pressure-lowering effects of the medications, possibly altering its effectiveness or increasing their spread over the diet. Limiting alcohol intake is recommended while using this medication.

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What is the use of Cialis?

Cialis is an oral drug used to treat erectile dysfunction (impotence). Cialis works by helping you to get and maintain an erection. It belongs to a group of drugs known as phosphodiesterase type 5 (PDE 5) inhibitors. This medication is used to treat impotence in men. This medication is used to treat the symptoms of benign prostatic hyperplasia (BPH), a condition that enlarges the prostate gland in men. This medication works by relaxing the muscles in the prostate and bladder, allowing for easier urination.

How does Cialis work?

Cialis belongs to a group of drugs called PDE5 inhibitors. This medication works by blocking the action of an enzyme called cGMP. cGMP is a substance that relaxes the smooth muscles in the prostate and bladder to allow easier urination.

Cialis comes in several strengths and dosages. The dosage and duration of Cialis will depend on your medical condition, age, and response to treatment. The maximum recommended daily dose of Cialis is 20 milligrams (mg).

How long does Cialis last?

The effects of Cialis can last for up to 36 hours after being ingested. Cialis will remain active for up to 5 hours. Cialis will start working within 15 minutes of being taken, and it will stay active for up to 4 hours.

Can you take Cialis if you’re under 18?

No, Cialis is not recommended for people who are 18 years of age or older. Cialis is safe for use in children under 18 years of age. Do not use Cialis if you are allergic to tadalafil or cialis. Cialis and other PDE5 inhibitors can cause serious side effects.

What is the best dosage for Cialis?

For most men, Cialis can be taken with or without food. The recommended dose of Cialis is 10 milligrams (mg). The maximum recommended daily dose of Cialis is 20 mg. The dosage of Cialis for erectile dysfunction is 5 mg/day. The maximum recommended daily dose of Cialis is 100 mg.

You can buy Cialis online at a local pharmacy or pharmacy. You can get Cialis tablets and Cialis oral jelly online from the following sites:

  • www.lillypharm.com
  • www.genericpharmacy.com

If you are taking other medications, you may also need to consult your doctor before using Cialis. Cialis can interact with other drugs and should not be used together.

Can I take Cialis at any time?

There is no known interaction between Cialis and alcohol. However, you may still drink alcohol while taking Cialis.

Can Cialis be used to treat benign prostatic hyperplasia?

Cialis is not approved for use in the treatment of benign prostatic hyperplasia (BPH). However, it is sometimes used to treat other conditions such as pulmonary arterial hypertension, and may also be used in some cases of prostate cancer.

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What are the possible side effects of Cialis?

Side effects of Cialis are usually mild to moderate in severity. The most common side effects of Cialis are headache, flushing, indigestion, back pain, muscle aches, stuffy nose, and stuffy or runny nose.

Eli Lilly and Company (NYSE: LLY) and GlaxoSmithKline (NYSE: GSK) today announced that the company’s subsidiary, Eli Lilly and Company, will receive a $2.3 million grant for the project, which will include:

  • FDA-approved new drug application (NDA) for tadalafil;
  • FDA-approved new drug application (NDA) for sildenafil, the active ingredient in the prescription drug Viagra;
  • FDA-approved new drug application (NDA) for vardenafil, the active ingredient in the prescription drug Levitra; and
  • FDA-approved new drug application (NDA) for cialis, the active ingredient in the prescription drug Cialis.

The grant will be awarded to Eli Lilly & Company for the research and development, marketing, and commercialization of Cialis, a generic version of Viagra. The grant will also support Eli Lilly & Company’s efforts to commercialize tadalafil as an affordable generic alternative to the brand-name drug Cialis.

“Eli Lilly and Company has been recognized for the incredible work it has done to commercialize the new treatment for benign prostatic hyperplasia and will continue to be a leader in this important area,” said John P. Smith, President and CEO of Eli Lilly and Company. “We are very excited to partner with this groundbreaking product and look forward to delivering this important new product for the treatment of this life-threatening condition.”

Eli Lilly & Company will make a total of approximately $1 billion in annual sales to its current shareholders in approximately 10 months.

Lilly, which has more than 3,500 employees in more than 130 countries, is committed to providing access to quality, affordable, high-quality healthcare. The Company’s most significant product, Cialis, and the company’s largest product, the new treatment for benign prostatic hyperplasia (BPH), has been on the market for more than five decades and has been shown to be safe, effective and cost-effective.

For more information about Eli Lilly and Company, visit www.eli Lilly and Company.

For more information about the Company and its product development, please visit www.lillyand Company.com.

Lilly and Company

As the leading pharmacy and healthcare business organization, Eli Lilly & Company is committed to the highest quality, affordable, and innovative healthcare. The company is committed to delivering meaningful progress toward its goal of bringing to you the best treatment for your specific medical condition.

For more information about Eli Lilly and Company, please visit www.eli Lilly and Company.

Eli Lilly and Company is headquartered in Indianapolis, Indiana. The company is ranked No. 2 in the country by IQVIA, with a product approval rating of 75% from more than 400 pharmaceutical companies. It is ranked No. 5 in the country by the Business Media Association. Eli Lilly & Company operates 13 major pharmacy and healthcare companies, all of which are focused on the treatment of conditions such as benign prostatic hyperplasia (BPH), a common condition affecting about 20% of men with BPH. These healthcare businesses are based in and around Indianapolis, Indiana. In addition to the company, there are over 100 other healthcare businesses in the country. Eli Lilly & Company also has operations throughout the United States and abroad.

The Lilly and Company leadership team consists of:

  • Dr. David Smith, MD, who is CEO of the Indianapolis Healthcare Group;
  • Thomas Lippmann-Scheraffen, MD, MD, Vice President, Global Development, U. S. Government Health Care;
  • Michael L. Johnson, MD, who is Vice President of Global Corporate Affairs, Lilly and Company;
  • Edward C. Johnson, MD, who is the CEO of the Indianapolis Healthcare Group;
  • Mr. David S. O’Brien, MD, the CEO and Chairman of the Lilly and Company;
  • Henry E.

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